منابع مشابه
The dystrophin-associated protein complex.
The lethal muscle-wasting disorder, Duchenne muscular dystrophy, is caused by mutations or deletions in the dystrophin gene. In skeletal and cardiac muscle, dystrophin associates with various proteins to form the dystrophinassociated protein complex (DAPC). The DAPC is thought to play a structural role in linking the actin cytoskeleton to the extracellular matrix, stabilizing the sarcolemma dur...
متن کاملA review of Biology and clinical use of Mesenchymal stem cell: an immune -modulator progenitor cell
Human mesenchymal stem cells (hMSCs), which also called mesenchymal stromal cells, are multipotent stem cell. Human MSCs typically are positive for the surface markers CD44, CD73, CD90, CD105, CD106, and also negative for hematopoietic markers CD34 and CD45.These cells can be isolated from postnatal bone marrow, adipose tissue, placenta, and scalp tissue, as well as from various fetal tissues. ...
متن کاملCharacterization and localization of a 77 kDa protein related to the dystrophin gene family.
The Duchenne muscular dystrophy gene gives rise to transcripts of several lengths. These mRNAs differ in their coding content and tissue distribution. The 14 kb mRNA encodes dystrophin, a 427 kDa protein found in muscle and brain, and the short transcripts described encode DP71, a 77 kDa protein found in various organs. These short transcripts have many features common to the deduced primary st...
متن کاملSplice site selection in the dystrophin gene
The dystrophin gene is the largest gene in the human genome, and it codes for a protein which plays an important role in anchoring the cytoskeleton to the cell membrane. Mutations in the gene may cause Duchenne muscular dystrophy (DMD) or Becker muscular dystrophy (BMD), an allelic variant. Currently genetic therapy holds great promise in finding a cure through exon skipping by restoring the pr...
متن کاملGene and Protein Networks 5th European Conference on Computational Biology
Network models 8 Graph and network definitions . . . . . . . . . . . . . . . . . . 9 Data sources and databases . . . . . . . . . . . . . . . . . . 11 Random graphs . . . . . . . . . . . . . . . . . . . . . . . . . 13 Small World networks . . . . . . . . . . . . . . . . . . . . . . 15 Change in network research . . . . . . . . . . . . . . . . . . . 17 Scale-free networks . . . . . . . . . . . ....
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ژورنال
عنوان ژورنال: Journal of the Royal Society of Medicine
سال: 1997
ISSN: 0141-0768,1758-1095
DOI: 10.1177/014107689709000921